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Read
this issue
and
previous
issues online.
Announcements / Press
Releases
EDCTP
Newsletter, August 2008 [EDCTP]
— (English)
Executive
Director's Note, News about EDCTP
Governance, News about Calls and Grants,
Funded projects, Meetings and Visits,
Events ...
End Malaria –
Blue Ribbon Campaign Engages Families from
Lesoma Village in Botswana [MFI]
— (English)
Botswana and
United States teachers and students are
working together with the support of the
American Embassy, the Ministry of Health,
local government officials, and the
Malaria Foundation International (MFI) to
engage community leaders and families from
the Lesoma Village, Chobe District of
Botswana in today's global fight against
malaria. A recent village campaign to End
Malaria in this village and encourage
international leadership among students to
help fight the disease globally followed a
Malaria Education Workshop held at the
Gaborone Secondary School (GSS)....
Current
Vacancies at Malaria Consortium
[Malaria Consortium] — (English)
Uganda;
Advocacy Manager, UK; Consultancy Work:
Short-term...
Support to the
National Malaria Programme, Nigeria: A
DFID-Funded Project 2008-2012
[Malaria Consortium] — (English)
The aim of
the project is to manage a package of
support DFID is providing to the
Government of Nigeria in support of the
national effort to control malaria. The
project also aims to strengthen the
delivery of Nigeria's National Malaria
Control effort through improving capacity
at all levels and through provision of
commodities for effective prevention and
treatment of malaria...
Genzyme
Corporation and MMV Announce New
Collaboration with Advinus Therapeutics to
Accelerate Discovery of Novel Therapies
for Malaria [MMV Press Release]
— (English)
Genzyme
Corp., a global leader in biotechnology,
and Medicines for Malaria Venture (MMV), a
not-for-profit virtual research and
development (R&D) organization dedicated
to reducing the burden of malaria,
announced today a new collaboration with
India’s Advinus Therapeutics Ltd. The
collaboration seeks to develop new,
improved treatments for specific patient
groups most at risk for malaria, an often
fatal infectious disease of developing
countries, particularly affecting pregnant
women and infants...
ICMM publishes
Guidance on HIV/AIDS, TB and Malaria
[ICMM Press Release] — (English)
ICMM’s Good
Practice Guidance on HIV/AIDS, TB and
Malaria, which is aimed at managers and
health practitioners, provides practical
information for disease management...
1.09.2008
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Monkey
Malaria in a European Traveler
Returning from Malaysia [EID
Journal, Volume 14, Number 9–September
2008] — (English)
In 2007,
a Finnish traveler was infected in
Peninsular Malaysia with Plasmodium
knowlesi, a parasite that usually
causes malaria in monkeys. P. knowlesi
has established itself as the fifth
Plasmodium species that can cause
human malaria. The disease is
potentially life-threatening in
humans; clinicians and laboratory
personnel should become more aware of
this pathogen in travelers...... |
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Utahns
work to land funds for malaria nets
for Africa [Deseret News -
Salt Lake City,UT,USA] — (English)
Nets for
Africa was started by Brandon Rodman,
a Brigham Young University graduate
who said there were no Utah-based
groups fighting malaria...... |
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No sting
in AMC's anti-mosquito campaign
[Times of India - India] —
(English)
According to AMC authorities, out of
total 13.38 lakh houses surveyed
between August 4 and August 12 for
mosquito breeding, 19,694 houses were
found to be positive, despite malaria
drive by AMC. However, according to
AMC officials the slide positivity
rate of malaria has shown a decline in
comparison with last year...... |
31.08.2008
30.08.2008
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Campaign
of spreading insecticide to combat
malaria in Mahweet started
[Yemen News Agency - Yemen] —
(English)
Medical
teams in Mahweet governorate started
on Saturday a campaign of spreading
insecticide to combat malaria...... |
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High
Quality Anti-Malaria Drugs Will
Significantly Reduce Malaria Related
Deaths in Africa [Modern
Ghana - Ghana] — (English)
One of
the groups leading a relentless
crusade to turn the tide is Africa
Fighting Malaria (AFM), a health
advocacy group based in South Africa
and the USA.With a mission to make
malaria control more transaparent,
responsive and effective, AFM is today
leading the first grass roots project
dedicated to buying high quality
malaria drugs for African children and
testing markets in Africa to publicize
the prevalence of fake sub standard
malaria drugs...... |
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City is
the malaria capital of state
[Daily News & Analysis - Mumbai,India]
— (English)
This is
one distinction that the civic
authorities could have done without.
Mumbai has topped the list of
malaria-affected districts in
Maharashtra and has even defeated
Gadchiroli that is usually the
worst-affected region in the
state...... |
29.08.2008
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US,
Tanzania Leaders Discuss Malaria
[Voice of America - ] — (English)
U.S.
President George Bush and Tanzanian
President Jakaya Kikwete met Friday at
the White House to talk about fighting
malaria. VOA White House Correspondent
Scott Stearns has the story...... |
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We're at
war with malaria - Kikwete
[IPPmedia - Dar es Salaam,United
Republic of Tanzania] — (English)
President Jakaya Kikwete has said
Tanzania is fighting an all-out war
against malaria, adding that the
country would kick out the killer
disease if effective strategies were
put in place...... |
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Ghana to
hold seminar aimed at increasing NGO
capacity to fight HIV/AIDS, TB,
malaria [News-Medical.net -
Sydney,Australia] — (English)
The
African Grassroots NGO Capacity
Building Seminar -- scheduled for
Sept. 15 to Sept. 17 in Accra, Ghana
-- aims to increase fundraising and
program implementation capacity of 60
nongovernmental organizations in
Africa working to address HIV/AIDS,
tuberculosis and malaria on the
continent, This Day reports...... |
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Malaria
patients rising [Gorkhapatra
- Kathmandu,Nepal] — (English)
outbreak
of malaria has gripped the southern
VDCs of Nawalparasi district
recently...... |
28.08.2008
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Deux cas de paludisme autochtone
signalés en France
[Le Monde - France] — (French)
Deux cas de paludisme autochtone ont
été signalés en France par le centre
hospitalier de Nice, chez un couple de
jeunes Parisiens n'ayant pas voyagé
dans une zone de présence du parasite,
a annoncé, mercredi 27 août, la
Direction générale de la santé
(DGS)...... |
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Deux cas de «paludisme d'aéroport»
signalés en France
[Libération - France] — (French)
Cette forme rare de paludisme a été
détectée hier chez un couple de
parisiens ayant séjourné à proximité
de l'aéroport de Roissy...... |
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Retour de vacances, attention au
paludisme !
[Ouest France -
France] — (French)
La France est le pays d'Europe le plus
touché par cette maladie.
25 % des
crises sont détectées au mois de
septembre...... |
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Exodus
Film Group and "Igor" Join Forces With
the "Against Malaria Foundation" and
Malaria.com to Fight the Disease, One
Bed Net at a Time [MarketWatch
- USA] — (English)
Exodus
Film Group, Malaria.com, and the
Against Malaria Foundation today
announced their partnership to help
rid the world of the disease with the
help of Igor, the title character in
Exodus' upcoming animated feature
"Igor" opening nationwide on September
19 distributed by Metro-Goldwyn-Mayer.
In the movie, Igor lives in the
fictional land of Malaria and ends up
unwittingly eradicating evil from his
world and changing his life...... |
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Multiple
insecticide resistance mechanisms
involving metabolic changes and
insensitive target sites selected in
anopheline vectors of malaria in Sri
Lanka [Malaria Journal
2008, 7:168 (28 August 2008)] —
(English)
Article
brings a wide range of data on
insecticide resistance of several
malaria vectors from Sri Lanka...... |
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Uganda's
Makerere University receives AMANET
grant for malaria vaccine trial
[News-Medical.net - Sydney,Australia]
— (English)
The
College of Health Sciences at Uganda's
Makerere University will receive a
grant from the African Malaria Network
Trust to begin trials of the malaria
vaccine candidate GMZ2 in Uganda's
Iganga and Mayuge districts, Wen
Kilama, managing trustee of AMANET,
said Monday at the opening of the
sixth Basic Research Ethics Workshop
for African Ethics Committees, the New
Vision reports...... |
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Uganda:
Curtain Mosquito Nets Launched
[New Vision (Kampala) via
allAfrica.com] — (English)
THE
first mosquito net curtains have been
launched in the country. Primary
health state minister, Emmanuel Otaala,
who presided over the launch in
Kampala, said Uganda spends 10% of its
budget on malaria...... |
27.08.2008
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BASF
Donate Interceptor Malaria Nets to
Cyclone Victims [Azom.com -
USA] — (English)
BASF
donated 100,000 INTERCEPTOR® malaria
nets to the relief efforts following
cyclone Nagris in Myanmar. The company
channeled 75,000 nets through the
well-known U.K. based emergency
response agency “The MENTOR
Initiative” and another 25,000 nets
through the Thailand Red Cross...... |
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100.000
Moskitonetze schützen in Myanmar vor
sich ausbreitenden Krankheiten
[die news - Germany ] — (Deutsch)
BASF
spendet im Rahmen der Hilfsaktionen
nach dem Zyklon Nargis in Myanmar
100.000 INTERCEPTOR®-Moskitonetze. Das
Unternehmen schickte 75.000
Moskitonetze über die bekannte
britische Hilfsorganisation The MENTOR
Initiative in das Krisengebiet,
weitere 25.000 Netze über das
thailändische Rote Kreuz...... |
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Reduced
paediatric hospitalizations for
malaria and febrile illness patterns
following implementation of
community-based malaria control
programme in rural Rwanda
[Malaria Journal 2008, 7:167] —
(English)
A paper
presenting interesting data on the
effectiveness evaluation of the
wide-scale implementation of ITNs and
community-based malaria
treatment...... |
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The
economic burden of malaria on the
household in south-central Vietnam
[Malaria Journal 2008, 7:166] —
(English)
This is
a cluster-based randomized trial to
evaluate the efficacy of long-lasting
insecticidal hammocks for the control
of malaria in the mountainous and
forested provinces of south-central
Vietnam, inhabited by the Raglay
ethnic minority, a largely
self-sustaining farming
community...... |
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Unforeseen
misuses of bed nets in fishing
villages along Lake Victoria
[Malaria Journal 2008, 7:165] —
(English)
In this
lakeshore fishing community, there is
considerable misuse of bed nets for
drying fish and fishing. Many
villagers are not yet fully convinced
of the effectiveness of LLINs for
malaria prevention...... |
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Integrated
vector management: the Zambian
experience [Malaria Journal
2008, 7:164] — (English)
A paper
describing steps to implement
integrated vector management as part
of a National Malaria Programme.
Itdescribes the historical steps
leading to the adoption of IVM and
represents a detailed description of
how IVM has been developed and
employed in Zambia...... |
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Insertion
polymorphisms of SINE200
retrotransposons within speciation
islands of Anopheles gambiae molecular
forms [Malaria Journal
2008, 7:163] — (English)
The
approach utilized allowed to develop
new easy-to-use co-dominant markers
for the analysis of genetic
differentiation between M and S-forms
and opens new perspectives in the
study of the speciation process
ongoing within A. gambiae...... |
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Rwanda:
Excitement As Indoor-Spraying to
Control Malaria Gets Underway
[Rwanda News Agency/Agence Rwandaise
d'Information (Kigali) via
allAfrica.com] — (English)
Rwanda
this week relaunched the
indoor-insecticide spraying program to
control the spread of malaria in
Kigali. For Vestine Mukagasana, the
spraying comes at the right time...... |
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Angola:
Rate of Malaria Deaths Drops
[BuaNews (Tshwane)] — (English)
The rate
of death associated with malaria in
Angola has dropped from 25 000 in 2003
to 7 000 last year as a result of the
expansion of the sanitation services
network, coupled with the peace the
country won in 2002...... |
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Sénégal: Paludisme à Bambey - Constat
d'une nette régression
[Agence de Presse
Sénégalaise (Dakar) via allAfrica.com]
— (French)
Les nombreuses interventions des
Organisations communautaires de base
(OCB) ont contribué à diminuer la
prévalence du paludisme à Bambey
(centre), a appris l'APS auprès du
médecin-chef du district sanitaire du
département...... |
26.08.2008
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Host
control of malaria infections:
constraints on immune and
erythropoeitic response kinetics
[PLoS Comput Biol. 2008 Aug
22;4(8):e1000149] — (English)
Our
results challenge some standard
assumptions. For example, we show that
tight synchronization of the asexual
reproduction of malaria parasites may
actually benefit the host by reducing
parasitemia. We also demonstrate that
properties of host immunity or
erythropoiesis that contribute to high
parasitemia and severe anemia in P.
falciparum malaria would do so in P.
vivax infection as well, in line with
recent reports indicating that P.
vivax can indeed cause “malignant”
illness in some patients. This
suggests that P. falciparum is more
effective overall at immune evasion or
suppression than P. vivax...... |
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Detection
of genome wide polymorphisms in the AT
rich Plasmodium falciparum genome
using a high density microarray
[BMC Genomics. 2008 Aug 25;9(1):398] —
(English)
A large
number of mSFP were discovered from
the P. falciparum genome using a high
density microarray, most of which were
in clusters of highly polymorphic
genes at chromosome ends. Our method
for accurate mSFP detection and the
mSFP identified will greatly
facilitate large scale studies of
genome variation in the P. falciparum
parasite and provide useful resources
for mapping important parasite
traits...... |
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Genzyme in
charitable partnership to end malaria
[Boston Herald - USA] — (English)
In an
effort to eliminate malaria,
Cambridge-based biotechnology company
Genzyme Corp. has joined forces with
an international disease fighter and
another biotech firm. Genzyme,
Medicines for Malaria Venture of
Switzerland and India-based Advinus
Therapeutics Ltd. are developing new
treatments for malaria, an often fatal
infectious disease that claims up to 2
million lives each year...... |
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Malaria
vaccine warrants more support
[ScienceAlert - Australia] —
(English)
In 2002
the World Health Organisation
estimated there were ~400000 clinical
cases of malaria and 1–2 million
deaths annually...... |
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Makerere
to try out malaria vaccine
[New Vision - Kampala,Uganda] —
(English)
MAKERERE
University Medical School is preparing
to carry out trials on a malaria
vaccine. The African Malaria Network
Trust (AMANET) has announced that the
GMZ2 vaccine trials will be carried
out in Iganga and Mayuge
districts...... |
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What Next
in Battle against HIV/AIDS, TB and
Malaria? [This Day] —
(English)
HIV/AIDS, tuberculosis and malaria
have been identified as three major
pandemics that are ravaging the
African continent. Friend Africa, an
organisation at the fore-front in the
fight against these diseases is
stepping up the battle with a summit
for various non-governmental
organisations on the continent in
Ghana next month. Roland Ogbonnaya
writes...... |
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Genetically manipulated virus could
prevent mosquitoes from transmitting
malaria, study says [News-Medical.Net]
— (English)
A
genetically manipulated version of
densovirus could prevent Anopheles
gambiae mosquitoes from transmitting
malaria, according to a study
published last week in PLoS Pathogens,
the New York Times reports...... |
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Indian
physicians concerned about malaria
drug resistance, recommend combination
therapy [News-Medical.Net]
— (English)
India
has reported an increase in
drug-resistant malaria cases this
year, leading physicians to express
concern and recommend that the disease
be treated with a combination of
drugs, India's Daily News and Analysis
reports...... |
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Sénégal: Traitement du Paludisme - Le
test de diagnostic rapide pour
rationaliser l'Act
[Le Soleil (Dakar) via allAfrica.com]
— (French)
Les Journées de mobilisation contre le
paludisme menées dans la commune de
Tambacounda par les nouveaux
assistants infirmiers du Centre
régional de formation en santé (Crfs)
en partenariat avec l'Ong espagnole
Enfermera para El Mundo ont été mises
à profit pour expliquer le Test
diagnostic rapide (Tdr) dans les dix
quartiers où des causeries sont
prévues avec les populations...... |
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Sénégal: Consultations gratuites et
don de moustiquaires - Le village de
Bambey Sérère et environ ciblé
[Le Soleil (Dakar) via allAfrica.com]
— (French)
L'université de Bambey a organisé le
23 août 2008 à l'intention des
populations de Bambey Sérère et
villages environnants, une journée de
consultations gratuites et de remise
de moustiquaires imprégnées...... |
Articles requiring
subscription
Structure of
the DBL3x domain of pregnancy-associated
malaria protein VAR2CSA complexed with
chondroitin sulfate A [Nature
Struct Mol Biol. 2008 Aug 24] — (English)
Plasmodium
falciparum-infected erythrocytes bind to
chondroitin sulfate A (CSA) in the
placenta via the VAR2CSA protein, a member
of the P. falciparum erythrocyte membrane
protein-1 family, leading to
life-threatening malaria in pregnant women
with severe effects on their fetuses and
newborns. Here we describe the structure
of the CSA binding DBL3x domain, a Duffy
binding-like (DBL) domain of VAR2CSA. By
forming a complex of DBL3x with CSA
oligosaccharides and determining its
structure, we have identified the CSA
binding site to be a cluster of conserved
positively charged residues on subdomain 2
and subdomain 3. Mutation or chemical
modification of lysine residues at the
site markedly diminished CSA binding to
DBL3x. The location of the CSA binding
site is an important step forward in the
molecular understanding of
pregnancy-associated malaria and offers a
new target for vaccine development...
Plasmodium
falciparum and Helminth Coinfection in a
Semiurban Population of Pregnant Women in
Uganda [The Journal of
Infectious Diseases 2008;198:920–927] —
(English)
Hookworm–P.
falciparum coinfection and M. perstans–P.
falciparum coinfection among pregnant
women in Entebbe is more common than would
be expected by chance. Further studies are
needed to elucidate the mechanism of this
association. A helminth-induced increase
in susceptibility to P. falciparum could
have important consequences for pregnancy
outcome and responses to P. falciparum
infection in infancy...
Pregnancy-Associated Malaria Affects
Toll-Like Receptor Ligand–Induced Cytokine
Responses in Cord Blood [The
Journal of Infectious Diseases
2008;198:928–936] — (English)
P.
falciparum infection history during
pregnancy appears to have a pronounced
effect on neonatal innate immune
responses. The observed effects may have
profound implications for the outcome of
newly encountered infections in early
life...
Potential use
of birthweight indicators in rural
Tanzania for monitoring malaria control in
pregnancy [Public Health,
Volume 122, Issue 9, September 2008, Pages
923-932 ] — (English)
Birthweight
indicators show that malaria control in
pregnancy is poor in this population,
deteriorates with distance of place of
birth from the main hospital location, and
is worst in adolescent primigravidae.
Greater attention should be given to the
use of birthweight indicators in rural
areas of Tanzania for monitoring malaria
control in pregnancy...
A study on
pathogenicity and mosquito transmission
success in the rodent malaria parasite
Plasmodium chabaudi adami
[International Journal for Parasitology,
2008 Aug 8] — (English)
We
investigated the parasitology,
pathogenicity (virulence) and infectivity
to mosquitoes of blood infections in mice,
of two strains, DS and DK, of the rodent
malaria parasite Plasmodium chabaudi adami.
Blood infections of DS were found to be
highly pathogenic; the asexual parasites
in these infections were fast-growing and
showed no evidence of selectivity in their
infection of host erythrocytes...
Microfluidic
approaches to malaria pathogenesis
[Cellular Microbiology, 27 Aug 2008] —
(English)
Here we
review the recent introduction of
microfluidic technology to study malaria
pathogenesis, including the fabrication
processes. The devices are cheap,
versatile, portable and require very small
patient samples. With greater use in
research laboratories and field sites, we
eventually expect microfluidic methods to
play important roles in malaria diagnosis,
as well as prognosis...
Artemisinins:
their growing importance in medicine
[Trends Pharmacol Sci. 2008 Aug 25] —
(English)
In this
review, we discuss recent advances in
defining the role of artemisinins in
medicine, with particular focus on their
controversial mechanisms of action. This
safe and cheap drug class that saves lives
at risk from malaria can also have
important potential in oncology...
Sickle Cell
Trait is Associated with a Delayed Onset
of Malaria: Implications for Time-to-Event
Analysis in Clinical Studies of Malaria
[The Journal of Infectious Diseases
2008;198:000–000 ] — (English)
Given the
delay in the time to first malaria episode
associated with HbAS, it would be
advisable for clinical trials and
observational studies that use this end
point to include Hb typing in the design
of studies conducted in areas where HbAS
is prevalent...
Human Genetics
and Malaria: Relevance for the Design of
Clinical Trials [The Journal of
Infectious Diseases 2008;198:000–000] —
(English)
Concern
about genetic factors and study outcomes
should extend beyond vaccine studies.
Genetics can affect treatment outcomes, as
was demonstrated in a recent study that
showed sulfadoxinepyrimethamine treatment
to be approximately half as likely to fail
in children with sickle cell trait,
compared with children who had normal
hemoglobin. Adding extensive genetic
assessments to all malaria treatment
efficacy studies may be impractical.
Nonetheless, recent characterizations of
the impact of human genetics on malaria
outcomes, including the report in this
issue, remind us of the powerful impact of
falciparum malaria on human evolution and
therefore of the need to consider human
genetics as one assesses malaria
outcomes...
Computer-Aided
Design and Synthesis of Nonpeptidic
Plasmepsin II and IV Inhibitors
[ChemMedChem. 2008 Aug 27] — (English)
Plasmepsins
(Plm) II (EC number: 3.4.23.39) and IV (EC
number: 3.4.23.B14) are aspartic proteases
present in the food vacuole of the malaria
parasite Plasmodium falciparum and are
involved in host hemoglobin degradation.
Based on our established efficient
synthetic sequence, a series of inhibitors
for Plm II and IV has been synthesized
bearing a 2,3,4,7-tetrahydro-1H-azepine
scaffold as the core structural element...
Apoptosis of
endothelial cells in bacterial sepsis and
severe Plasmodium falciparum malaria: do
we know enough to consider clinical
trials? [Crit Care Med. 2008
Sep;36(9):2690-2] — (English)
By Mzayek F,
Ylöstalo J, Krogstad DJ....
Recombinant
scorpine: a multifunctional antimicrobial
peptide with activity against different
pathogens [Cell Mol Life Sci.
2008 Aug 23] — (English)
The
recombinantly expressed scorpine (RScp) in
Anopheles gambie cells showed
antibacterial activity against Bacillus
subtilis and Klebsiella pneumoniae, at 5
and 10 μM, respectively. It also produced
98% mortality in sexual stages of
Plasmodium berghei at 15 μM and 100%
reduction in Plasmodium falciparum
parasitemia at 5 μM. RScp also inhibited
virus dengue-2 replication in C6/36
mosquito cells...
Arginine,
nitric oxide, carbon monoxide, and
endothelial function in severe malaria
[Curr Opin Infect Dis. 2008
Oct;21(5):468-75] — (English)
Replenishment of arginine and restoration
of nitric oxide production in clinical
malaria should diminish parasitized red
blood cells adherence to endothelium and
reduce the sequelae of these interactions
(e.g. cerebral malaria). Arginine therapy
given in addition to conventional
antimalaria treatment may prove to be
beneficial in severe malaria...
Imaging
effector functions of human cytotoxic
CD4(+) T cells specific for Plasmodium
falciparum circumsporozoite protein
[Int J Parasitol. 2008 Aug 6] — (English)
these
findings suggest that CD4+ CTLs trigger
target cell apoptosis via classical
perforin/granzyme-mediated cytotoxicity,
similar to CD8+ CTLs, and these
multifunctional sporozoite- and
peptide-induced CD4+ T cells have the
potential to play a direct role as
effector cells in targeting the
exoerythrocytic forms within the liver...
Isolation and
characterization of Plasmodium falciparum
UAP56 homolog: Evidence for the coupling
of RNA binding and splicing activity by
site-directed mutations [Arch
Biochem Biophys. 2008 Aug 9] — (English)
Using the
parasite extract we report that PfU52 is
involved in splicing reaction.
Site-directed mutagenesis studies indicate
that the conserved residues glycine 181,
isoleucine 182 and arginine 206 are
involved in RNA binding and this activity
is required for the enzymatic activities
of PfU52. PfU52 is expressed in all the
intraerythrocytic developmental stages of
the parasite. In the present study we have
reported the detailed characterization of
PfU52 from P. falciparum and these results
advance the knowledge regarding the
function of UAP56 in general...
Molecular
markers of in vivo Plasmodium vivax
resistance to amodiaquine plus
sulfadoxine-pyrimethamine: mutations in
pvdhfr and pvmdr1 [The Journal
of Infectious Diseases 2008;198:409–417] —
(English)
The present
study identified a new molecular marker in
pvmdr1 that is associated with the in vivo
response to AQ+SP. We suggest suitable
marker sets with which to monitor P. vivax
resistance against AQ+SP in countries
where these drugs are used...
Prepared in cooperation
with European Commission HIV/AIDS in South
Africa. |
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